CDR3

C.S.RAMAN raman at BIOC01.UTHSCSA.EDU
Wed Sep 27 18:25:28 EST 1995


Hello:

Has anyone come across hydrophobic amino acid clusters in the CDRs
(particularly CDR3) of heavy chain repertoires?  For that matter, is
there documented evidence for very hydrophobic CDRs in general.  My
understanding (via Padlan's review) is that aliphatic amino acids are
the least represented in the CDRs. 

Any information on this subject would be highly appreciated.

Cheers
-raman
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   _/                           C.S.RAMAN                                  _/
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