microbial toxin and CD8+ activation

Jean Content jcontent at ben.vub.ac.be
Thu Apr 4 12:04:03 EST 1996


I'm currently working with some bacterial proteins which can stimulate, when added in 
soluble form, CD8+ T cells in bulk culture and sensitize target cells for killing.
I suspect that the recognized Ag is a toxin with a "cell invasive activity".
Does anybody work on this topic? somewhere. I would like to know if this property is 
a common feature of bacterial toxins. I know that the adenylate cyclase of bordetella 
pertussis can also penetrate eukariotic membrane.

thanks a lot 




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