Antibodies agaist highly comserved proteins

Mplnt mplnt at
Sun Apr 14 23:51:59 EST 1996

I had to make alot of monoclonal antibodies to tumour markers that were
highly conserved.  The way I did them was to do in vitro immunization.  IN
this manner it takes out many if not all of the constraints of self during
the process.  It worked well and we made monoclocals to some very hightly
conseved regions.  Try looking at some of the work out of Baylor College
of Medicine around 1982.

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