Immunodominance

Tom Thatcher ttha at uhura.cc.rochester.edu
Wed Apr 24 10:10:36 EST 1996


In <4lkidc$1go at vixen.cso.uiuc.edu> afong at uiuc.edu writes:

>What are some mechanisms of immunodominance?  I know that CD4+ T cells can 
>exhibit immunodominance of peptide determinants, but just curious into 
>the probable mechanisms.

Immunodominance also applies to CD8 and B cell responses.

Read Sercarz's review of Immunodominance in the 1994 (I think)
Annual Review of Immunology.  It's definitely in Ann. Rev. Immunol.
for some recent year.  It is quite comprehensive.  On the other
hand, he totally ignores one important additional mechanism (which I
will tell you about after I publish :)

-- 
Tom Thatcher                          | You can give a PC to a Homo habilis,
University of Rochester Cancer Center | and he'll use it, but he'll use it
ttha at uhura.cc.rochester.edu           | to crack nuts.



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