Abzymes as vaccines?

volm timothy gerard tvolm at blue.weeg.uiowa.edu
Thu Aug 15 16:49:05 EST 1996


	Was wondering if anyone had heard of using abzymes ( catalytic 
antibodies) as vaccines. For example, would it be possible to incorporate 
statine ( a transition state analogue ) into a protein, then use that 
protein to raise antibodies that would function as a protease to that 
protein. ( say to the fusion protein of HIV )?
	I recall someone had tried to make an abzyme esterase for 
cocaine, but never read much more about that. 

					Thanks, Tim

Tim Volm




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