Neocortical Immunomodulation in Humans

Jeffrey Smoot jsmoot at
Thu Aug 29 14:04:10 EST 1996

Stavros Zanos wrote:
> Im interested in any references concerning the role of neocortical
> activity (and its laterality) in the modulation of immune responses in
> humans. Im aware of a paper by Kang et al.(1991), and placing a number
> of MedLine querries did not give a result.
> Thank you for any help.
> Kang et al. (1991) Behav. Neurosci. 105:860-69
> --
> Stavros P. Zanos
> Aristotle University School of Medicine
> Thessaloniki, Greece

Here's a reference which I hope will assist you and I believe is in line with
what you're looking for.

Jeffrey Smoot
Chemical Abstract Services            Phone    614-447-3600 X3198
P.O. Box 3012                         E-mail   mailto: jsmoot at
Columbus, OH 43210                    WWW
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TI   Differences in serum interleukin-6 (IL-6) between healthy dextral and
     non-dextral subjects

AU   Chengappa, K.N. Roy; Ganguli, Rohan; Yang, Zan W.; Schurin, Galina;
     Brar, Jaspreet S.; Rosenbleet, Jodi A.; Rabin, Bruce S.
CS   Department of Psychiatry, Western Psychiatric Institute and Clinic,
     Pittsburgh, PA, USA

SO   Neurosci. Res. (Shannon, Irel.) (1994), 20(2), 185-8

AB   Serum interleukin-6 (IL-6) was measured in picograms/mL (pg/mL) using
     an immunoassay (ELISA) in healthy individuals (n = 148), of whom 128
     were classified as dextral and 20 as non-dextral, as per a laterality
     questionnaire.  Only 3 (15%) non-dextral individuals had serum IL-6
     levels above the lower limit of the assay sensitivity as compared to
     59 (46%) of dextral individuals (P < 0.013).  There were no
     significant correlations between previously detd. mitogen stimulated
     interleukin-2 prodn. and autoantibodies in a subset of the same
     individuals.  While this data does not provide causal information, it
     adds to the evidence of the asym. regulation of immune functions by
     the cerebral hemispheres.

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