TNT and immunology

Jeffrey Smoot jsmoot at cas.org
Fri Aug 30 06:23:16 EST 1996


Scheffer Stephan wrote:
> 
> Hy, i am looking for some information about
> phagocytic cells, contaminated with
> trinitrotoluene(TNT).
> 
> Thanks a lot, Stephan Scheffer
> Universitat Marburg ,Germany
> 
> email: scheffer at papin.hrz.uni-marburg.de

Stephan, perhaps this will help.
-- 
Jeffrey Smoot
Chemical Abstract Services            Phone    614-447-3600 X3198
P.O. Box 3012                         E-mail   mailto: jsmoot at cas.org
Columbus, OH 43210                    WWW      http://www.cas.org
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TI   Effects of trinitrotoluene (TNT) metabolites on chemiluminescence
     response of phagocytic cells

AU   Thierfelder, Wulf; Masihi, K. Noel

CS   Robert Koch Inst., Berlin, D-13353, Germany

SO   Int. J. Immunopharmacol. (1995), 17(5), 453-6

AB   The effects of TNT metabolites on the generation of activated oxygen
     species was investigated by a sensitive luminol-dependent
     chemiluminescence (CL) assay.  Spleen cell suspensions contg.
     2,4-diaminotoluene, 2,4,6-triaminotoluene, 2-amino-6-nitrotoluene,
     4-amino-3,5-dinitrotoluene and 2-amino-4,6-dinitrotoluene were
     stimulated with zymosan.  Aminotoluenes and amino-nitrotoluenes
     induced a dose-dependent inhibition of CL response.  The mixed
     substituted toluenes generally required higher doses than
     aminotoluenes for the suppression of CL response which was not due to
     the cytotoxic redn. of cell viability.  CL appears to be a
     well-suited assay for detn. of the immunotoxic potential of diverse
     mols. on phagocytic cells of the immune system.


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