Transgenic T-cell receptor mice

Volker Blaschke vblasch at gwdg.de
Tue Dec 3 07:39:34 EST 1996


Dear fellow netters,

I wonder if someone could answer this question that came to me AFTER 
hearing a talk on peripheral tolerance:

What kind of T-cell receptor to T-cell receptor transgenic mice express 
on their T-cells? I figured the single T-cell should express both 
receptors, the indigenous and the transgenic, but I wonder if there is a 
kind of bilateral exclusion so that only one kind of receptor is 
expressed and therefore there would be a subpopulation of T-cells 
expressing the transgenic receptor. Does anyone know to what percentage 
this subpopulation can build up to?

Thanks in advance for any input!

  Volker

-- 
Dr. Volker Blaschke
Depts. of Biochemistry, Dermatology
Georg-August-University, Goettingen, Germany
Email: vblasch at gwdg.de
Tel: xx49 551 39 5959 / 5978



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