Oxidative Stress

[T Ichim]

I am wondering if anybody has checked what influence exogenous oxidative 
stress e.g. H2O2 plays on the sphingomyelinase pathway of signal 
transduction.  The reason why I ask this is because I think I remember 
reading a long time ago that oxidative stresses tend to upregulate 
phospholipase A2 activity and it has recently been shown that 
phospholipase A2 is activated by agents which utilize the ceramide 
transduction pathway such as IL-1 and TNF-alpha.