Low Immuno-activity in DM

T Ichim TEICHIM at AHS.watstar.uwaterloo.ca
Wed Feb 21 22:15:34 EST 1996


Dear Dr. Kasihara

     I read your posting with much interest and I have some questions for 
you.  First you say that "High levels of ACTH  are reserved to lower the 
blood glucose level of patients which causes apoptosis in lymphocytes"  
Do the lymphocytes undergo apoptosis because of too little glucose or 
just because of the ACTH?

      Second, you said that recognition of antigen by lymphocytes can be 
altered by steric hinderance induced by glucose molecules.  Do you have 
any more information of ideas about how that may work?




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