SEEKING INFO:Nickel Allergy --IMMUNOPATHOGENESIS
jsmoot at cas.org
Thu Feb 22 16:28:14 EST 1996
Stuart Krasnoff wrote:
> I just read an article on nickel allergy in the Feb 1996 Berkeley Wellness
> Newsletter. I'm curious about these allergies to non-proteinaceous
> materials, Nickel, and organics like formaldehyde, urushiol (poison ivy
> I just looked through Biosis for informative abstracts on nickel allergy
> and it looks like simple nickel compounds like nickel sulfate are indeed
> capable of inducing antibody formation. Can non-peptidal molecules,
> induce antibody formation by themselves? Don't they have to be complexed
> to some protein or other? Is this what happens with nickel compounds?
> One abstract refers to an unidenditified "Ni-induced antigen". Is this
> some presumptive Ni-protein complex. If so where does the protein
> component come from? Are allergies of this type IGE mediated? Are
> symptoms histamine-mediated? Can anybody refer to (or summarize) a
> textbook-level model for immunopathogenesis of Nickel allergy. How about
> for formaldehyde, urushiol?
> Post or email.
Stuart, here's a pointer for you.
Chemical Abstract Services
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ANSWER 11 OF 169 CAPLUS COPYRIGHT 1996 ACS
TI Interaction of palladium ions with the skin
AU Santucci, B.; Cristaudo, A.; Cannistraci, C.; Picardo, M.
CS Servizio di Allergologia, San Gallicano, Italy
SO Exp. Dermatol. (1995), 4(4, Pt. 1), 207-10
CODEN: EXDEEY; ISSN: 0906-6705
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