nickel allergy - Seeking info on Immunopathogenesis??

[Pietr Hitzig]

Nickel allergy, I believe, is Th1 driven. Therefore not IgE or histamine 
related.  

Dopamine is a Th1 agonist and a Th2 antagonist. Serotonin (5-HT) is a Th1 
antagonist and a Th2 agonist. (See Devoino et al. UI:88285053 and 
Romagnani Ann. Rev. Immunology, 12:227 1994

Clinically, the combo of a DA and 5-HT agonist (FEN/PHEN) can totally 
immunomodulate.  I am getting remission of Sjogren's, SLE, cutaneous 
lupus, psoriasis. Promising clinical responses in HIV, MS, ALS. 

See http://www.fenphen.com for further references. Especially RR Brown et 
al.  

Tryptophan is crucial to everything. Tyrosine probably too.