In article <v02140a03ad21f6f5dbcd@[136.142.20.45]>,
Aki Hoji <akhst7+ at PITT.EDU> wrote:
>I would like to obtain any infomation regarding the functions as well as
>distributions of CD68L. Is there evidence suggesting that CD68L playing a
>role in T lymphocyte homing ? Any help will be appreciated.
Personally, never heard of it's involvement, but then I've not really
followed this molecule...
Quick medline search led to:
Strobl H; Scheinecker C; Csmarits B; Majdic O; Knapp W.
Flow cytometric analysis of intracellular CD68 molecule expression in
normal and malignant haemopoiesis.
British Journal of Haematology, 1995 Aug, 90(4):774-82.
(UI: 95399271)
Abstract: CD68 molecules are heavily glycosylated lysosomal membrane
constituents of unknown function with strong expression in monocytes and
macrophages. Using flow cytometry, we quantified expression levels of CD68
molecules in normal and malignant haemopoietic cells. CD68 molecules are
intensely expressed in the cytoplasm and weakly on the surface of mature
CD14+ monocytes. CD68 expression seems to start very early during
granulomonopoietic differentiation. Virtually all myeloperoxidase (MPO)+
bone marrow cells coexpress CD68 and similar proportions of CD34+
progenitor cells weakly express CD68 or MPO molecules. During further
differentiation, CD68 expression is strongly up-regulated in early MPO+
precursor cells which lack lactoferrin (LF) and CD14 molecules. Compared to
these, more mature MPO+LF+ bone marrow and peripheral blood granulocytes
express considerable lower levels of CD68. In-line with this broad
expression, all investigated acute myeloid leukaemia (AML) cases,
classified as FAB M1-M5, were CD68 positive, and compared to normal CD34+
bone marrow cells. CD34+ AML blast cells expressed increased levels. CD68
expression is, however, not restricted to cells of myeloid origin, because
a subset (40 +/- 15%, n = 6) of CD19+ peripheral blood B-lymphocytes and
50% of B-ALL are also weakly positive. In contrast, normal CD3+ lymphocytes
lack (< 3%, n = 6) CD68 and only low proportions (6 +/- 3%, n = 6) of CD56+
NK cells are CD68+. Also, all investigated T-ALL cases (n = 6) lacked CD68.
--
"Nothing more is needed to destroy a man, than the conviction that his
life's work is useless." -Antonin Artaud
awarnock at cmgm.stanford.edu (R. Aaron Warnock)
