IUBio

Need Advice on Freeze Drying Antibodies

David John Pritchard Dave at djpritch.demon.co.uk
Thu Jan 18 15:13:00 EST 1996


I want to freeze dry antibodies (particularly in plasma from people
with autoimmune diseases), as a means of long term storage. In my 
attempts so far I have frequently seen a significant drop in titre 
either immediately upon freeze drying or after a couple of months 
storage at 2-8 degrees C.

Does anybody have any experience of successfully freeze drying 
antibodies, and if so any advice on suitable protocols, additives to 
enhance stability etc. would be very welcome.

Thanks

Dave


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* 	Dave Pritchard							*	
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*	EMail Dave at djpritch.demon.co.uk                                 *   
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