antibodies for single sugars?

ALussow alussow at aol.com
Mon Jan 22 02:01:37 EST 1996


Antibodies can recognize disaccharides.  The human anti gal alpha1-3gal
response that is the major barrier to xenotransplantation is a case in
point.  Those antibodies differentiate between the a1-3 and a b1-4
linkage.
To develop your own anti-sugar monooclonals you first have to couple the
sugar to a carrier protein and then immunise a non-tolerant host.

Good luck,
Alex
If you don't ask much from life, that's what you'll get.



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