Anti-HLA Class I MAb

Kiley R. Prilliman kprillim at rex.re.uokhsc.edu
Wed Jun 5 18:03:39 EST 1996


...what do you mean by "framework" antibody?  One that specifically 
binds the heavy chain in a native-molecular state?  I would think it 
would be easier to use an antibody to the light chain 
(b2-microglobulin), since there is quite a bit of "species-specificity" 
with such antibodies.  (For example, the MAb to human b2m, BBM.1, will 
bind to human and chimpanzee MHC class I but NOT to mouse or even baboon 
molecules).



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