burns at sasa.gov.uk (Robert Burns) wrote:
>Hi folks,
> have any of you heard of haemophiliacs developing anti-
>human factor 8 antibodies as a result of treatment. It sounds a
>bit improbable to me but just wanted to check if any of you had
>come across it.
>thanks
>Rob
>Robert Burns
>Monoclonal Antibody Unit
>Scottish Agricultural Science Agency
>East Craigs
>Edinburgh
>Scotland
>burns at sasa.gov.uk
A high ( i think about 30 %) of severe haemophilia A patients ( no
detectable factor 8) get "auto" antibodies. Why is this so surprising
? I would think (no immunologist) that all of them would get these
antibodies during their long term treatments with this non-self
antigen.
Greetings Tom
Tom Vink
Department of Haematology
University Hospital Utrecht
The Netherlands
