Polly Matzinger's theory

dr._jack_komisar at WRSMTP-CCMAIL.ARMY.MIL dr._jack_komisar at WRSMTP-CCMAIL.ARMY.MIL
Mon Jun 17 06:41:55 EST 1996

          As far as I can see, nobody has addressed the question of
          *positive* selection of thymocytes.  Negative selection can
          be accomodated within the theory, but positive selection
          violates the rules for thymocytes in Dr. Matzinger's article
          in Annual Review of Immunology.  It may allow danger signals
          to be recognized at some later time, but when it occurs it
          is self/nonself discrimination.
             (I am responding by e-mail because my institution does
          not carry Usenet).

                                                  Jack Komisar

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