LPS inhibition of CYCLOHEXIMIDE superinduction

ian ian at net.au
Thu Jun 27 18:22:38 EST 1996

I am currently working on an LPS inducible gene which is 
superinducible by cycloheximide (CHX), no problem. However, when LPS 
and CHX are added together, expression is completely abrogated. I 
could understand if the level was either greater than LPS alone or at 
least as great as CHX alone. It seems that in the presence of CHX, LPS 
acts as an inhibiter instead of an inducer. Has anyone seen this 
before or can anyone offer an explanation?


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