John B. wrote:
>> Hello,
>> I'm a second year physiology student and am seeking information on the presentation of antigenic peptides by MHC class I and class II
> molecules. I'd appreciate if anyone can suggest any review articles that covers this material.
>> Thank you very much.
>> John B.
I'm not sure how specific you want to get, but the Heemels and Ploegh
article in Annual Reveiews of Biochemistry 1995 64:463-91 "Generation,
Translation, and Presentation of MHC Class-I Restricted Peptides" is
tough to beat as an up to date critical review. IMHO. It does leave
out some detail on membrane proteins. It also buys too much the
prevailing dogma on IFNgamma/LMP2/LMP7 and proteasome changes which is
all based on non-physiologic fluoropeptide substrates. But hey, thats
the mantra thats been published in science and nature and immunity, etc
and its such a nice story everybody else repeats it too. But I digress.
(I'm writing my thesis proposal on peptide generation for Class I in
Vic Engelhard's lab and am up to my eyeballs in papers and opinions on
the subject.) Good luck.
