Teresa's S/O and G/O hypothesis: Resp to Weiskirch

Teresa Binstock binstoct at essex.UCHSC.edu
Sun Mar 10 12:56:58 EST 1996

Teresa responds to Larry W:

On Fri, 8 Mar 1996, Larry Weiskirch wrote:
> I... wondered whether there was any experimental basis for your 
> hypothesis, beyond the published work you allude to. 

As far as I know, not yet; although the Lee Ellis and colleague paper I 
cited in a recent post in this thread did review findings about 
experimental autoimmune manipulations toward LHRH-related neurons, with the 
result being bisexual male mice -- not quite the mechanisms my hypothesis 
points toward, but important nonetheless.

> Until some data is generated, this will be little more than a 
> seemingly improbable hypothesis based on rather shaky logic. 

Because ste2 and ste3 do occur in human thymic epithelium and many 
cellular components (including GnRH) are quite homologous between yeast and 
humans, I would appreciate elucidation regarding the "shakiness of the 

> Nevertheless, I think it would 
> be enormously interesting if any data existed supporting this connection; 
> as you probably know, the notion that the nervous system affects the 
> immune system is quite controversial...

Cites for six recent reviews follow my sign-off hereinbelow.

> I look forward to seeing any results you obtain.

Thanks for the encouragement. In a subsequent post I'll outline a 
starting point for researching my "S/O G/O immuno-basis" hypothesis and 
request people e-mail me suggestions for experimental protocols -- and 
post them to lists only as appropriate.


Teresa C. Binstock, Researcher
Developmental & Behavioral Neuroanatomy
Denver CO USA
			Teresa.Binstock at uchsc.edu

			 ***       ***       ***

Six references re: PsychoNeuroImmunology

Gee AL et al
Behaviorally conditioned modulation of natural killer cell activity:
enhancement of baseline and activated natural killer cell activity.
International Journal of Neuroscience 1994 Jul;77(1-2):139-52

Maier SF et al
Psychoneuroimmunology. The interface between behavior, brain, and
      immunity. [Review]
American Psychologist 1994 Dec;49(12):1004-17

Laudenslager ML
Research perspectives in psychoneuroimmunology IV, 1993.
Psychoneuroendocrinology 1994;19(8):751-63

Flach J  &  Seachrist L
Mind-body meld may boost immunity [news].
Journal of the National Cancer Institute 1994 Feb 16;86(4):256-8

Solomon GF
Whither psychoneuroimmunology? A new era of immunology, of
      psychosomatic medicine, and of neuroscience. [Review]
Brain, Behavior, & Immunity 1993 Dec;7(4):352-66

Kropiunigg U
Basics in psychoneuroimmunology. [Review]
Annals of Medicine 1993 Oct;25(5):473-9


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