M. Doherty M_Doherty at NIH.gov
Tue Mar 12 10:16:35 EST 1996

In article <o0c9869-1103961814490001 at ppp0d-02.rns.tamu.edu>,
o0c9869 at tam2000.tamu.edu wrote:

> Interesting questions for immunologists:
> What do you think is the fate of viral DNA inside a macrophage?.
> Possible ways for viruses to get to infect a macrophage?
> Is the viral particle phagocitized by the macrophage, or gets inside by
> another way?.

I think you'll need to be a little more specific.

What kind of viruses are you interested in?  Depending on virus
species/strain there are probably almost as many ways to get into
monocytes as there are surface features.  What happens next depends on the
virus, the state of activation of the macrophage, and the surrounding
(cytokine/costimulation) milieu.

Cheers, Mark

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