My apologies for the following very speculative association.
By chance I read 2 postings, one was on the the transition of HIV
patients from AIDS negative to AIDS positive symptoms where the latter is
eventually overwhelmed by HIV infection. The other was on transformation of
bacilli and it brought back memories of competency and transformation taught
by Dr. Pakula, one of the discoverers of this biological trait. Are the two
Genetic mutations occur on a regular basis. Does the body have a
mechanism of competency/transformation in which it regularly checks its
genetic make-up? Essentially this would be a type of genetic integrity by
cellular consensus. This might explain other phenomena such as centripetal
infection (e.g. rabies), ageing (if competency is regulated by a hormone,
shutting down this hormone would shut down cellular consensus), increased
rate of Down's syndrome for elderly women, and the development of AIDS
(RNA -> DNA ->lysogeny, genetically overwhelming the system).