Teresa's S/O and G/O hypothesis: Resp to Robinson

Teresa Binstock binstoct at essex.UCHSC.edu
Wed Mar 13 13:05:46 EST 1996

On 13 Mar 1996, Keith Robison wrote:
> Trying to draw a link between yeast mating and human gender determination
> via GCR isn't particularly compelling; GCR's are ubiquitous.

However, many yeast genes are homologous to mammalian genes, including 
certain human genes. Some mammalian gene products function similarly in 
yeast, some yeast products function in mammalian tissues. The fact that 
ste2 and ste3 are expressed in human T cells and perhaps elsewhere 
suggests that there may be some aspect of preserved function. 

The fact that most G-protein related events may be ubiquitous does not 
disprove specific examples -- especially given the growing number of 
yeast/human genes known to function similarly in both species. 

To present an outlandish example: the jury did not find Ted Bundy not 
guilty by virtue of the fact that most white males are not like Ted 

I highly recommend references 4 and 5 of the prior post for persons 
wanting to develop an overview of yeast genes and their functional 
homologues in humans. 


Teresa C. Binstock, Researcher
Developmental & Behavioral Neuroanatomy
Denver CO USA
			Teresa.Binstock at uchsc.edu

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