On 13 Mar 1996, Keith Robison wrote:
>> ste2 and ste3 belong to the G-protein coupled receptor (GCR) superfamily,
> and large family used for many purposes including vision (rhodopsin).
>> Trying to draw a link between yeast mating and human gender determination
> via GCR isn't particularly compelling; GCR's are ubiquitous.
>> Keith Robison
> Harvard University
Teresa responds:
1. Belonging to a superfamily does not mean that all members of the
superfamily are functionally interchangable.
2. ste2 and ste3 are membrane-spanning receptors and are not G-proteins,
but are linked to G-proteins (J Biol Chem 268.11.8070-7 1993).
3. The fact that "GCR's are ubiquitous." (Robison, 1996) does not address
the rationale of Teresa's hypothesis regarding sexual- and
gender-orientations.
4. The link between ste2 and ste3 and human thymic epithelium is actual
and suggests that immune mechanisms of self and not-self and related
"alternative regulations" in autoimmune phenomena might induce altered
interpretation of sexually significant chemo-molecules arriving at the
nasal mucosa, thereby resulting in altered sexual and/or gender
orientation.
Teresa
Some ste2, ste3 and G-protein references:
1
TI - Regulation of cellular calcium through signaling cross-talk involves
an intricate interplay between the actions of receptors, G-proteins,
and second messengers. [Review]
SO - FASEB Journal 1995 Oct;9(13):1297-303
2
TI - Structural and functional relationships of heterotrimeric
G-proteins. [Review]
SO - FASEB Journal 1995 Aug;9(11):1059-66
3
TI - The family of G-protein-coupled receptors. [Review]
SO - FASEB Journal 1995 Jun;9(9):745-54
4
TI - STE2/SCG1-dependent inhibition of STE4-induced growth arrest by
mutant STE4 delta C6 in the yeast pheromone response pathway.
SO - FEBS Letters 1995 Jun 26;367(2):122-6
5
TI - Protein kinases that phosphorylate activated G protein-coupled
receptors. [Review]
SO - FASEB Journal 1995 Feb;9(2):175-82
6
TI - Direct evidence for ligand-induced internalization of the yeast
alpha-factor pheromone receptor.
SO - Molecular & Cellular Biology 1994 Nov;14(11):7245-55
7
TI - Membrane organization in G-protein mechanisms. [Review]
SO - FASEB Journal 1994 Sep;8(12):939-46
8
TI - The third cytoplasmic loop of a yeast G-protein-coupled receptor
controls pathway activation, ligand discrimination, and receptor
internalization.
SO - Molecular & Cellular Biology 1994 May;14(5):3339-49
9
TI - The pheromone receptors inhibit the pheromone response pathway in
Saccharomyces cerevisiae by a process that is independent of their
associated G alpha protein.
SO - Genetics 1993 Dec;135(4):943-53
10
TI - Pheromone action regulates G-protein alpha-subunit myristoylation in
the yeast Saccharomyces cerevisiae.
SO - Proceedings of the National Academy of Sciences of the United States of
America 1993 Oct 15;90(20):9688-92
11
TI - Disruption of receptor-G protein coupling in yeast promotes the
function of an SST2-dependent adaptation pathway.
SO - Journal of Biological Chemistry 1993 Apr 15;268(11):8070-7
12
TI - Molecular and functional diversity of mammalian Gs-stimulated
adenylyl cyclases. [Review]
SO - FASEB Journal 1993 Jun;7(9):768-75
13
TI - Emerging concepts in the Ras superfamily of GTP-binding proteins.
[Review]
SO - FASEB Journal 1993 Jun;7(9):750-9
14
TI - Pheromone response in yeast. [Review]
SO - Annual Review of Biochemistry 1992;61:1097-129
15
TI - Rhodopsin and phototransduction: a model system for G protein-linked
receptors. [Review]
SO - FASEB Journal 1992 Mar;6(6):2323-31
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