Teresa's S/O and G/O hypothesis: Resp2 to Robison

Teresa Binstock binstoct at essex.UCHSC.edu
Wed Mar 13 18:32:21 EST 1996

On 13 Mar 1996, Keith Robison wrote:
> ste2 and ste3 belong to the G-protein coupled receptor (GCR) superfamily,
> and large family used for many purposes including vision (rhodopsin).
> Trying to draw a link between yeast mating and human gender determination
> via GCR isn't particularly compelling; GCR's are ubiquitous.
> Keith Robison
> Harvard University

Teresa responds: 

1. Belonging to a superfamily does not mean that all members of the 
superfamily are functionally interchangable.

2. ste2 and ste3 are membrane-spanning receptors and are not G-proteins, 
but are linked to G-proteins (J Biol Chem 268.11.8070-7 1993).

3. The fact that "GCR's are ubiquitous." (Robison, 1996) does not address 
the rationale of Teresa's hypothesis regarding sexual- and 

4. The link between ste2 and ste3 and human thymic epithelium is actual 
and suggests that immune mechanisms of self and not-self and related 
"alternative regulations" in autoimmune phenomena might induce altered 
interpretation of sexually significant chemo-molecules arriving at the 
nasal mucosa, thereby resulting in altered sexual and/or gender 


Some ste2, ste3 and G-protein references:

TI  - Regulation of cellular calcium through signaling cross-talk involves
      an intricate interplay between the actions of receptors, G-proteins,
      and second messengers. [Review]
SO  - FASEB Journal 1995 Oct;9(13):1297-303

TI  - Structural and functional relationships of heterotrimeric
      G-proteins. [Review]
SO  - FASEB Journal 1995 Aug;9(11):1059-66

TI  - The family of G-protein-coupled receptors. [Review]
SO  - FASEB Journal 1995 Jun;9(9):745-54

TI  - STE2/SCG1-dependent inhibition of STE4-induced growth arrest by
      mutant STE4 delta C6 in the yeast pheromone response pathway.
SO  - FEBS Letters 1995 Jun 26;367(2):122-6

TI  - Protein kinases that phosphorylate activated G protein-coupled
      receptors. [Review]
SO  - FASEB Journal 1995 Feb;9(2):175-82

TI  - Direct evidence for ligand-induced internalization of the yeast
      alpha-factor pheromone receptor.
SO  - Molecular & Cellular Biology 1994 Nov;14(11):7245-55

TI  - Membrane organization in G-protein mechanisms. [Review]
SO  - FASEB Journal 1994 Sep;8(12):939-46

TI  - The third cytoplasmic loop of a yeast G-protein-coupled receptor
      controls pathway activation, ligand discrimination, and receptor
SO  - Molecular & Cellular Biology 1994 May;14(5):3339-49

TI  - The pheromone receptors inhibit the pheromone response pathway in
      Saccharomyces cerevisiae by a process that is independent of their
      associated G alpha protein.
SO  - Genetics 1993 Dec;135(4):943-53

TI  - Pheromone action regulates G-protein alpha-subunit myristoylation in
      the yeast Saccharomyces cerevisiae.
SO  - Proceedings of the National Academy of Sciences of the United States of
      America 1993 Oct 15;90(20):9688-92

TI  - Disruption of receptor-G protein coupling in yeast promotes the
      function of an SST2-dependent adaptation pathway.
SO  - Journal of Biological Chemistry 1993 Apr 15;268(11):8070-7

TI  - Molecular and functional diversity of mammalian Gs-stimulated
      adenylyl cyclases. [Review]
SO  - FASEB Journal 1993 Jun;7(9):768-75

TI  - Emerging concepts in the Ras superfamily of GTP-binding proteins.
SO  - FASEB Journal 1993 Jun;7(9):750-9

TI  - Pheromone response in yeast. [Review]
SO  - Annual Review of Biochemistry 1992;61:1097-129

TI  - Rhodopsin and phototransduction: a model system for G protein-linked
      receptors. [Review]
SO  - FASEB Journal 1992 Mar;6(6):2323-31


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