Teresa's S/O and G/O hypothesis: Resp2 to Robison
Michael Plautz (BIO)
mplautz at chuma.cas.usf.edu
Fri Mar 15 00:47:33 EST 1996
My G-proteins are no longer coupled since the divorce; I think the
transducer caught the Gs associating with adenyl cyclase again.
On Wed, 13 Mar 1996, Teresa Binstock wrote:
> On 13 Mar 1996, Keith Robison wrote:
> > ste2 and ste3 belong to the G-protein coupled receptor (GCR) superfamily,
> > and large family used for many purposes including vision (rhodopsin).
> > Trying to draw a link between yeast mating and human gender determination
> > via GCR isn't particularly compelling; GCR's are ubiquitous.
> > Keith Robison
> > Harvard University
> Teresa responds:
> 1. Belonging to a superfamily does not mean that all members of the
> superfamily are functionally interchangable.
> 2. ste2 and ste3 are membrane-spanning receptors and are not G-proteins,
> but are linked to G-proteins (J Biol Chem 268.11.8070-7 1993).
> 3. The fact that "GCR's are ubiquitous." (Robison, 1996) does not address
> the rationale of Teresa's hypothesis regarding sexual- and
> 4. The link between ste2 and ste3 and human thymic epithelium is actual
> and suggests that immune mechanisms of self and not-self and related
> "alternative regulations" in autoimmune phenomena might induce altered
> interpretation of sexually significant chemo-molecules arriving at the
> nasal mucosa, thereby resulting in altered sexual and/or gender
> Some ste2, ste3 and G-protein references:
> TI - Regulation of cellular calcium through signaling cross-talk involves
> an intricate interplay between the actions of receptors, G-proteins,
> and second messengers. [Review]
> SO - FASEB Journal 1995 Oct;9(13):1297-303
> TI - Structural and functional relationships of heterotrimeric
> G-proteins. [Review]
> SO - FASEB Journal 1995 Aug;9(11):1059-66
> TI - The family of G-protein-coupled receptors. [Review]
> SO - FASEB Journal 1995 Jun;9(9):745-54
> TI - STE2/SCG1-dependent inhibition of STE4-induced growth arrest by
> mutant STE4 delta C6 in the yeast pheromone response pathway.
> SO - FEBS Letters 1995 Jun 26;367(2):122-6
> TI - Protein kinases that phosphorylate activated G protein-coupled
> receptors. [Review]
> SO - FASEB Journal 1995 Feb;9(2):175-82
> TI - Direct evidence for ligand-induced internalization of the yeast
> alpha-factor pheromone receptor.
> SO - Molecular & Cellular Biology 1994 Nov;14(11):7245-55
> TI - Membrane organization in G-protein mechanisms. [Review]
> SO - FASEB Journal 1994 Sep;8(12):939-46
> TI - The third cytoplasmic loop of a yeast G-protein-coupled receptor
> controls pathway activation, ligand discrimination, and receptor
> SO - Molecular & Cellular Biology 1994 May;14(5):3339-49
> TI - The pheromone receptors inhibit the pheromone response pathway in
> Saccharomyces cerevisiae by a process that is independent of their
> associated G alpha protein.
> SO - Genetics 1993 Dec;135(4):943-53
> TI - Pheromone action regulates G-protein alpha-subunit myristoylation in
> the yeast Saccharomyces cerevisiae.
> SO - Proceedings of the National Academy of Sciences of the United States of
> America 1993 Oct 15;90(20):9688-92
> TI - Disruption of receptor-G protein coupling in yeast promotes the
> function of an SST2-dependent adaptation pathway.
> SO - Journal of Biological Chemistry 1993 Apr 15;268(11):8070-7
> TI - Molecular and functional diversity of mammalian Gs-stimulated
> adenylyl cyclases. [Review]
> SO - FASEB Journal 1993 Jun;7(9):768-75
> TI - Emerging concepts in the Ras superfamily of GTP-binding proteins.
> SO - FASEB Journal 1993 Jun;7(9):750-9
> TI - Pheromone response in yeast. [Review]
> SO - Annual Review of Biochemistry 1992;61:1097-129
> TI - Rhodopsin and phototransduction: a model system for G protein-linked
> receptors. [Review]
> SO - FASEB Journal 1992 Mar;6(6):2323-31
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