Teresa's S/O and G/O hypothesis: Resp2 to Robison

Michael Plautz (BIO) mplautz at chuma.cas.usf.edu
Fri Mar 15 00:47:33 EST 1996


My G-proteins are no longer coupled since the divorce; I think the 
transducer caught the Gs associating with adenyl cyclase again.

On Wed, 13 Mar 1996, Teresa Binstock wrote:

> On 13 Mar 1996, Keith Robison wrote:
> > 
> > ste2 and ste3 belong to the G-protein coupled receptor (GCR) superfamily,
> > and large family used for many purposes including vision (rhodopsin).
> > 
> > Trying to draw a link between yeast mating and human gender determination
> > via GCR isn't particularly compelling; GCR's are ubiquitous.
> > 
> > Keith Robison
> > Harvard University
> 
> 
> Teresa responds: 
> 
> 1. Belonging to a superfamily does not mean that all members of the 
> superfamily are functionally interchangable.
> 
> 2. ste2 and ste3 are membrane-spanning receptors and are not G-proteins, 
> but are linked to G-proteins (J Biol Chem 268.11.8070-7 1993).
> 
> 3. The fact that "GCR's are ubiquitous." (Robison, 1996) does not address 
> the rationale of Teresa's hypothesis regarding sexual- and 
> gender-orientations. 
> 
> 4. The link between ste2 and ste3 and human thymic epithelium is actual 
> and suggests that immune mechanisms of self and not-self and related 
> "alternative regulations" in autoimmune phenomena might induce altered 
> interpretation of sexually significant chemo-molecules arriving at the 
> nasal mucosa, thereby resulting in altered sexual and/or gender 
> orientation. 
> 
> 
> Teresa
> 
> Some ste2, ste3 and G-protein references:
> 
> 
> 1
> TI  - Regulation of cellular calcium through signaling cross-talk involves
>       an intricate interplay between the actions of receptors, G-proteins,
>       and second messengers. [Review]
> SO  - FASEB Journal 1995 Oct;9(13):1297-303
> 
> 2
> TI  - Structural and functional relationships of heterotrimeric
>       G-proteins. [Review]
> SO  - FASEB Journal 1995 Aug;9(11):1059-66
> 
> 3
> TI  - The family of G-protein-coupled receptors. [Review]
> SO  - FASEB Journal 1995 Jun;9(9):745-54
> 
> 4
> TI  - STE2/SCG1-dependent inhibition of STE4-induced growth arrest by
>       mutant STE4 delta C6 in the yeast pheromone response pathway.
> SO  - FEBS Letters 1995 Jun 26;367(2):122-6
> 
> 5
> TI  - Protein kinases that phosphorylate activated G protein-coupled
>       receptors. [Review]
> SO  - FASEB Journal 1995 Feb;9(2):175-82
> 
> 6
> TI  - Direct evidence for ligand-induced internalization of the yeast
>       alpha-factor pheromone receptor.
> SO  - Molecular & Cellular Biology 1994 Nov;14(11):7245-55
> 
> 7
> TI  - Membrane organization in G-protein mechanisms. [Review]
> SO  - FASEB Journal 1994 Sep;8(12):939-46
> 
> 8
> TI  - The third cytoplasmic loop of a yeast G-protein-coupled receptor
>       controls pathway activation, ligand discrimination, and receptor
>       internalization.
> SO  - Molecular & Cellular Biology 1994 May;14(5):3339-49
> 
> 9
> TI  - The pheromone receptors inhibit the pheromone response pathway in
>       Saccharomyces cerevisiae by a process that is independent of their
>       associated G alpha protein.
> SO  - Genetics 1993 Dec;135(4):943-53
> 
> 10
> TI  - Pheromone action regulates G-protein alpha-subunit myristoylation in
>       the yeast Saccharomyces cerevisiae.
> SO  - Proceedings of the National Academy of Sciences of the United States of
>       America 1993 Oct 15;90(20):9688-92
> 
> 11
> TI  - Disruption of receptor-G protein coupling in yeast promotes the
>       function of an SST2-dependent adaptation pathway.
> SO  - Journal of Biological Chemistry 1993 Apr 15;268(11):8070-7
> 
> 12
> TI  - Molecular and functional diversity of mammalian Gs-stimulated
>       adenylyl cyclases. [Review]
> SO  - FASEB Journal 1993 Jun;7(9):768-75
> 
> 13
> TI  - Emerging concepts in the Ras superfamily of GTP-binding proteins.
>       [Review]
> SO  - FASEB Journal 1993 Jun;7(9):750-9
> 
> 14
> TI  - Pheromone response in yeast. [Review]
> SO  - Annual Review of Biochemistry 1992;61:1097-129
> 
> 15
> TI  - Rhodopsin and phototransduction: a model system for G protein-linked
>       receptors. [Review]
> SO  - FASEB Journal 1992 Mar;6(6):2323-31
> 
> eof
> 
> 
> 



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