Teresa's S/O and G/O hypothesis: ste2,3 in humans
Ian A. York
iayork at panix.com
Thu Mar 14 16:48:22 EST 1996
In article <Pine.ULT.3.91.960314124251.9206A-100000 at essex.UCHSC.edu>,
Teresa Binstock <binstoct at essex.UCHSC.edu> wrote:
>Now, if Patel et al are using the symbols ste2 and ste3 for something
>totally different from yeast ste2 and ste3, then that is an important
>finding. Until we know that to be the case, the fact remains that Patel
>et al report that ste2 and ste3 ARE expressed in humans.
Perhaps if you read the paper, rather than the abstract, then you would
have been able to discover that important finding. Patel et al make no
reference to the yeast Ste genes, but are rather referring to unpublished
findings of their own. Their Ste1,2, and 3 are apparently unknown
molecules defined by particular monoclonals. Since they are working on
*S*urface *T*hymic *E*pithelial markers, I can make a pretty good
suggestion as to where they got the names.
Here is the full information they give on these markers: (p 82)
The following mAb from sources other than HLDA-V were also used: ... STE1
and STE2 (Hassal's bodies; D.D. Patel, L.P. Whichard. R.M. Scearce and
B.F. Haynes, unpublished); STE3 (thymic epithelium; D.D. Patel, L.P.
Whichard, R.M. Scearce and B.F. Haynes, unpublished) ...
Also from their Table II. Surface Reactivity of Non-HLDA-V Monoclonal
Antibodies to EK and TE cells (p. 86):
STE1 Hassall's bodies
STE2 Differentiated TE cells
STE3 TE cells
And from their discussion (p.90):
....The roles of increased CD12, CD38, CD47, CD55, CD66, CD87, TE4, and
STE3 are at present unclear.
...the etiology and relevance of the down-regulation of CDw65 and
STE2 molecules is unknown.
That's it. These molecules are almost certainly nothing to do with GCR's.
There is nothing in the literature showing anything like STE2 or STE3 in
humans. Medline pulls up only that article, plus half-a-dozen others
that used STE2 fusion proteins to express their human protein in yeast.
Genbank and Swissprot searches for STE2 AND HUMAN or STE3 AND HUMAN finds
no relevant genes.
I think you owe Keith an apology.
Ian York (iayork at panix.com) <http://www.panix.com/~iayork/>
"-but as he was a York, I am rather inclined to suppose him a
very respectable Man." -Jane Austen, The History of England
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