Teresa's S/O and G/O hypothesis: ste2,3 in humans

Ian A. York iayork at panix.com
Thu Mar 14 16:48:22 EST 1996


In article <Pine.ULT.3.91.960314124251.9206A-100000 at essex.UCHSC.edu>,
Teresa Binstock  <binstoct at essex.UCHSC.edu> wrote:
>
>Now, if Patel et al are using the symbols ste2 and ste3 for something 
>totally different from yeast ste2 and ste3, then that is an important 
>finding. Until we know that to be the case, the fact remains that Patel 
>et al report that ste2 and ste3 ARE expressed in humans. 

Perhaps if you read the paper, rather than the abstract, then you would 
have been able to discover that important finding.  Patel et al make no 
reference to the yeast Ste genes, but are rather referring to unpublished 
findings of their own.  Their Ste1,2, and 3 are apparently unknown 
molecules defined by particular monoclonals. Since they are working on 
*S*urface *T*hymic *E*pithelial markers, I can make a pretty good 
suggestion as to where they got the names.

Here is the full information they give on these markers: (p 82)
The following mAb from sources other than HLDA-V were also used: ... STE1 
and STE2 (Hassal's bodies; D.D. Patel, L.P. Whichard. R.M. Scearce and 
B.F. Haynes, unpublished); STE3 (thymic epithelium; D.D. Patel, L.P. 
Whichard, R.M. Scearce  and B.F. Haynes, unpublished) ...

Also from their Table II. Surface Reactivity of Non-HLDA-V Monoclonal 
Antibodies to EK and TE cells  (p. 86):

MAb                 Comment    

STE1            Hassall's bodies 
STE2            Differentiated TE cells
STE3            TE cells

And from their discussion (p.90):

....The roles of increased CD12, CD38, CD47, CD55, CD66, CD87, TE4, and 
STE3 are at present unclear. 
	...the etiology and relevance of the down-regulation of CDw65 and 
STE2 molecules is unknown.

That's it.  These molecules are almost certainly nothing to do with GCR's.

There is nothing in the literature showing anything like STE2 or STE3 in 
humans.  Medline pulls up only that article, plus half-a-dozen others 
that used STE2 fusion proteins to express their human protein in yeast.

Genbank and Swissprot searches for STE2 AND HUMAN or STE3 AND HUMAN finds
no relevant genes. 

I think you owe Keith an apology.

Ian
-- 
      Ian York   (iayork at panix.com)  <http://www.panix.com/~iayork/>
      "-but as he was a York, I am rather inclined to suppose him a
       very respectable Man." -Jane Austen, The History of England




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