Thalidomide, Melatonin, DHEA, TNF, and IL-2

Charles P. McCarthy pandoc at ix.netcom.com
Wed Nov 13 19:03:22 EST 1996


James Howard wrote:
[edit]
> My work suggests melatonin and DHEA act together in a cycle that is
> necessary for proper growth, development, and maintenance of all tissues.
> This material about melatonin and these cytokines further supports my
> theory of AIDS.  This all means that, in AIDS, as in aging, the melatonin -
> DHEA cycle has shut down.

All of the pathologically aberrant processes attending infection 
by HIV are a result of the activity of the viral glycoprotein 
gp120 that is secreted by infected host cells.  AIDS is the 
sequelae of this infection.

Numerous metabolic cycles are affected.  Gastric acid production 
by parietal cells is probably one of the earliest.  This and other
factors contribute to the phenomenon of wasting and interfere with
the growth and maintenance of host tissues.

All therapies designed to support host tissues and metabolic 
processes are limited in their approach by temporarily improving 
the generalized condition of the host without directly affecting 
the site of intimate contact between the viral protein and its 
host.  

A good analogy would be taking anti-venom while a rattlesnake
is still attached to your leg.  In the case of HIV, the gp120 it 
produces in host cells is like a rattlesnake with an inexhaustible 
supply of venom.  Like the rattlesnake, even after death the virus 
is capable of producing venom as isolation from the dead has 
revealed.

You can pump up your patient with all the nutrition and hormones
you like.  The question of outliving the snake is moot.  What is 
not open to argument is the painful reality of the loneliness of
the person to whom the snake is attached.

"Get thee behind me... "

Good luck and good hunting,

Charlie

Charles P. McCarthy, Clinical Specialist
Carmichael, CA USA



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