MEDICAL ADVICE NEEDED

[Gabor Csanyi]

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 URGENT MEDICAL ADVICE NEEDED
 ----------------------------


A 10 year old girl (Sophie) in Hungary has Diffuse Mesangiocapillare
Glomerulonephritis (I.) , her case as a young child is
unique in Hungary, doctors told her parents to seek advice from
abroad.

If you or someone you know is in this field of medicine, or you know a
similar case, please respond.

Any information would be greatly appreciated.

contact: borszeki at osiris.elte.hu    or    csanyi at mit.edu  
(Hungary)                                       (USA)
fax: +36-1 2226667                        tel: +1 (617) 2678509
tel: +36-30 334876                             +1 (617) 2536051
     +36-1 2528974


A report from Sophie's doctor follows.
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Summary

La'ng Zso'fia (Sophie Lang) born in Budapest 02/01/1986


In September 1994 an "acute postinfectional glomerulonephritis" has
developed and progressed. 
Among the labour measures, especially the "C-3 level" was very low.
After the end of the "acute period", proteinurea and the very low C-3
level proved to be persistent.

December 1994: a biopsy by syringe from the kidney recorded a "diffuse
endocapillar glumerulonephritis" with a considerable volume of C-3
deposition in the glumerulus substance.

An examination in Leiden verified a "C-3 nephritogenous factor
positivity".

Last year the proteinurea increased, proved to be of nephrotical
measure, ie 5.82 g/die.

Clinical symptoms of nephrosis did not develop. Hypertonia does not
exist.

In 1996.06 a new biopsy has taken place: diffuse mezangiocappillaris
glumerulonephritis (I.)

Considering the glomerural and secunder tubulointerstitial alterations
the progress proves to be significant. 

During the investigation of the centre of infection or any sources,
herpetic virus was found.


Budapest, 04/09/1996

Dr. Eva Gombos