CCR4 mutation

bkleine at bkleine at
Tue Sep 17 08:32:55 EST 1996

>Hello, I heard a mutation in the CCR4 gene is known to prevent the M 
>tropic HIV from infecting individuals.  I also believe it was found 
>that in European populations this mutation appears homozygously in approx 
>1% of the population and approx 30% heterozygously.  So since, most 
>likely, it hasn't been long enough for that specific human population to 
>"adapt" to HIV, why is the mutation or "HIV resistant" allele common in 
>that population?
>							Bear
You should read the original NATURE paper in July or August

Bernhard Kleine
Institute for Immunobiology
Freiburg Germany

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