How does it start?

Donald Forsdyke forsdyke at post.queensu.ca
Wed Aug 6 13:22:31 EST 1997

Chui Yiu Loon wrote:

> If a virus is smart enough, it should be able to evade immune
> attack by quietly and carefully replicating inside the cell without
> causing distress and transmitting its progeny to neighbouring cells via
> direct cell-cell contact. How successful is that strategy will in the
> end have to hang on to how sensitive is the host cell in detecting
> abnormality inside itself. Therefore, the crucial question remains: how
> does a cell start to know it has got an infection?
> I shall appreciate it very much if anyone can throw some light on this.
> Yiu-Loon Chui
> Chinese University of Hong Kong


      Well start by considering the case for INTRACELLULAR self/not-self
discrimination (see J. Biol.Systems Volume 3, 273-287 (1995).

                         Sincerely,  Donald Forsdyke

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