Rh heritability

Dom Spinella dspinella at chugaibio.com
Fri Dec 12 10:52:31 EST 1997


> What determines Rh + or - phenotype? Is it a simple dominant vs.
> recessive trait or something more complex?
> -MT

Actually, its quite bit more complicated than that.  There are three Rh
antigens (D Cc, and Ee) and two alternatively spliced structural genes
(RHD and RHCE). For a good review, see JP Cartron, "Defining the Rh
blood group antigens. Biochemistry and Molecular Genetics" Blood Rev. 8:
199-212 (1994).  Cheers.  -- Dom Spinella



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