Th1-Th2 / MHC dependent?

Paulo Santos psantos at gemini.ci.uc.pt
Tue Feb 4 03:07:26 EST 1997


I am trying to find out what is the level of dependence of Th1-Th2
polarization on MHC molecules (class II).
Some peptides presented through different MHC molecules are able induce
Th1 or Th2 responses, depending on several factors: APC type, tissue
environment, etc.
My question is: is there any evidence to assume that different
individuals could present a Th1 or Th2 response to the same pathogen
(e.g. M. tuberculosis), developing resistance or susceptibility,
influenced by their MHC molecules and the peptides they select for
presentation?

Thanks in advance, 

-- 
Paulo Santos
Centro de Histocompatibilidade do Centro - LUSOTRANSPLANTE
Faculdade de Medicina de Coimbra          Fax       +351-39-33674
piso 3  Apartado 3004                     Telephone +351-39-33693
P-3049 COIMBRA Codex  PORTUGAL                      +351-39-20527
.



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