Th1-Th2 / MHC dependent?

Paulo Santos psantos at
Tue Feb 4 03:07:26 EST 1997

I am trying to find out what is the level of dependence of Th1-Th2
polarization on MHC molecules (class II).
Some peptides presented through different MHC molecules are able induce
Th1 or Th2 responses, depending on several factors: APC type, tissue
environment, etc.
My question is: is there any evidence to assume that different
individuals could present a Th1 or Th2 response to the same pathogen
(e.g. M. tuberculosis), developing resistance or susceptibility,
influenced by their MHC molecules and the peptides they select for

Thanks in advance, 

Paulo Santos
Centro de Histocompatibilidade do Centro - LUSOTRANSPLANTE
Faculdade de Medicina de Coimbra          Fax       +351-39-33674
piso 3  Apartado 3004                     Telephone +351-39-33693
P-3049 COIMBRA Codex  PORTUGAL                      +351-39-20527

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