>In article <32F6EE3E.7779 at gemini.ci.uc.pt>, psantos at gemini.ci.uc.pt wrote:
>>>> My question is: is there any evidence to assume that different
>> individuals could present a Th1 or Th2 response to the same pathogen
>> (e.g. M. tuberculosis), developing resistance or susceptibility,
>> influenced by their MHC molecules and the peptides they select for
>> presentation?
>>>> Thanks in advance,
>>>> --
>> Paulo Santos
Kim Bottomly (at Yale) has presented data that the same peptide in the
context of 2 different MHC molecules can produce 2 different responses in
and in vitro culture system. The peptide binds well to I-A(s), driving Th1
development, and poorly to I-A(b), driving Th2 development. Alterations in
peptide binding affinities can be used to switch the responses.
Ken Frauwirth
--
Ken Frauwirth (MiSTie #33025) _ _
frauwirt at mendel.berkeley.edu |_) * |/ (_ |\ |
http://www.ocf.berkeley.edu/~frauwirt/ |_) | () |\ (_ | \|
DNRC Title: Chairman of Joint Commission on In-duh-vidual Affairs
