jeffj at u.washington.edu
Tue Feb 11 20:19:13 EST 1997
On Wed, 5 Feb 1997, Tom Thatcher wrote:
> mAbs are out of fashion, I think. If you use a mouse mAb the human patient
> eventually develops immunity against it which makes it ineffective
> as a treatment.
Which is why a lot of people have spent a lot of time and effort making
humanized antibodies during the past ten or so years. These consist of
mouse CDR's grafted onto human framework and constant regions. This
technique greatly reduces immunogenicity and makes antibody therapy a
realistic cancer treatment.
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