CD5+ b-lymphcyttes and immunity to polysaccharides

[Tor A Strand]

Adults have mostly CD5-  b-lymphocyttes, but before the age of 2 a lot of
b - lymphocyttes are CD5+. Is it so that CD5- lymphocyttes are better than
the other in mounting a immunresponse agains a t-cell independent antigen
like a pneumococcal polysaccharide.

Does anybody know what regulates these populations and the maturation of
b- cells.

How good does the population of lymphocyttes in the spleen reflect the
population in the blood?

-- 
Tor A Strand
Centre of International Health
University of Bergen 
Norway