Danger vs. self/non-self model

tom c. cigolott at nbnet.nb.ca
Mon Jul 7 19:26:59 EST 1997

In message <5pj2lv$1sf at panix.com> - iayork at panix.com (Ian A.
York)4 Jul 1997 10:51:43 -0400 writes:
}In article <5pbq32$n8k at agate.berkeley.edu>,
}Ken Frauwirth (BioKen) <frauwirt at bacillus.Berkeley.EDU> wrote:
}>room for significant overlap between them - they need not be mutually
}>exclusive.  Central tolerance seems to work on a self/non-self basis, while
}Absolutely.  Even peripherally, it seems likely that in many cases neither
}"non-self", nor "danger", alone is sufficient to inevitably trigger a


One guy who got a generalized reaction was Metchnikoff after
injecting finly ground activated charcoal into the abdominal
cavity. Aparently this was done prior to an operation to prevent
infection. Aparently2 there were humungous amounts of macrophages
waiting for something to show up to attack.

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