Why more HLA-DR ?

S.N. Imlach sni1 at le.ac.uk
Wed Jun 18 05:25:45 EST 1997

Why is more HLA-DR, in general, expressed on the surface of APC. According to 
my reading so far the same mechanisms for regulating the expression of HLA-DR
used for DP and DQ. Does this mean that the promptor activity in DR
is increased over the other Class II gene ? Does this overrepresentation
of HLA-DR confer any immunological advantage ?

Thanks in advance


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