Hello. In Stryer's Biochemistry textbook, he writes that MHC
molecules contain the consensus sequence of the antigen peptides that
they bind, "thus, peptides capable of being presented by an MHC protein
are homologus to a portion of the MHC protein itself." I have been
unable to find papers that mention this homology. No mention is made
of this in the recent reviews I've looked through.
Any leads? Thank you!
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Ho Leung Ng
holeung at ucla.edu