CTLA-8

Horst Ibelgaufts Ibelgauf at lmb.uni-muenchen.de
Wed Mar 26 06:01:22 EST 1997


In article <333898DB.4822 at AHS.watstar.uwaterloo.ca>, T Ichim
<TEICHIM at AHS.watstar.uwaterloo.ca> wrote:

* I was wondering if anyone can tell me about what CTLA-8 is?
* -- 
* 
* T Ichim


IL17: Interleukin-17. The cDNA encoding human IL17 was isolated from a
library of CD4 positive T-cells. It encodes a glycoprotein of 155 amino
acids sequence which exhibits 72 % amino acid identity with » HVS13, an
open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63 %
with murine CTLA-8 (cytotoxic T lymphocyte associated antigen 8).
High levels of an IL17 homodimer are produced by stimulated primary
peripheral blood CD4 positive T-cells. IL17 enhances expression of the
intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human
IL17 also stimulates epithelial, endothelial, or fibroblastic cells to
secrete IL6, IL8, and G-CSF and prostaglandin E2. In the presence of human
IL17, fibroblasts can sustain the proliferation of CD34 positive
hematopoietic progenitors and their preferential maturation into
neutrophils (see also: Hematopoiesis, Hematopoietic stem cells). 
Mouse, rat, and human IL17 can induce IL6 secretion in mouse stromal
cells, indicating that all homologs can recognize the mouse receptor. IL17
binds to a receptor that binds to HSV13 (referred to as viral IL17) and to
CTLA-8.
References: Fossiez F et al T cell interleukin-17 induces stromal cells to
produce proinflammatory and hematopoietic cytokines Journal of
Experimental Medicine 183(6): 2593-603 (1996); Kennedy J et al Mouse
IL-17: A cytokine preferentially expressed by  alpha  beta TCR+CD4-CD8- T
cells. Journal of Interferon and Cytokine Research   16(8): 611-617
(1996); Rouvier et al CTLA-8, cloned from an activated T cell, bearing
AU-rich messenger RNA instability sequences, and homologous to a
herpesvirus saimiri gene. Journal of Immunology 150(12): 5445-56 (1993);
Yao Z et al Human IL-17: a novel cytokine derived from T cells. J Immunol
155: 5483-6 (1995); Yao Z et al Herpesvirus Saimiri encodes a new
cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3(6):
811-21 (1995); Yao Z et al Complete nucleotide sequence of the mouse CTLA8
gene. Gene 168(2): 223-5 (1996)


regards

-- 


                                                   H IBELGAUFTS
http://www.lmb.uni-muenchen.de/groups/ibelgaufts/cytokines.html
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                                     Ultra posse nemo obligatur
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