A ? regarding NK cells

[S. MORI]

Hello Immunologists...
I have a question about NK cells... Is there any evidence for NK cells
migrating to the site of a solid tumour?? From what I know is that NK's
are largely found in the spleen while almost absent in the lymph nodes...
Can they migrate from blood vessels to a tumour? This of course
would require chemotactic signals for their attraction. Do we find solid
tumours infiltrated with NK cells? If so do you believe that a clonal
expansion is possible for NK cells?
Thanks a million for your help...

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Shahram Mori
Program in Molecular Biology
Department of Chemistry and Biochemistry Box 3C
New Mexico State University
Las Cruces NM
88003
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