NK Cells -- Senior Undergrad Biology/Immunology Student Needs your help.

Dave Peritt Peritt at mail.med.upenn.edu
Mon Sep 22 08:47:19 EST 1997


It is assumed that NK are roughly delineated at the pre T cell stage.  In
fact Nk cells have many similar markers and activities to T cells.  Some
suggest they are primordial and have remained due to their early entrance
into inflammatory sites.  We are working on various surface molecules that
are found on both NK and T cells.

Rag ko mice do not have B or T cells because of a disfunctional
rearrangement of the Ig or TcR respectively.  NK cells do not rearrange so
they exist in these mice.  Nude do not have T cells since thymic
maturation is neccessary yet NK cells exist.



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