Unique surface markers of activatied T lymphocyte

Kenneth Frauwirth kfrauwir at midway.uchicago.edu
Mon Dec 7 19:43:09 EST 1998


In article <366C37B3.1C8E at chugaibio.com>,
Dom Spinella <dspinella at chugaibio.com, @chugaibio.com> wrote:
>> would you please tell me that how many new unique surface molecules will
>> appear on the activated T cell membrane? Thanks.
>> 
>> Ningbo
>Your question assumes that all the possible surface markers of T-cell
>activation are known.  I doubt that's true.  Two markers that are widely
>used are HLA-DR (found of course on other cell types besides activated
>T-cells) 

But only on activated *human* T cells - murine T cells do not express
Class II MHC.

> and CD25 (the IL-2 receptor).  There are others...
>--Dom Spinella

Also commonly used are CD69 (a transient, early activation marker) and
CD44 (which remains expressed on memory cells).

Ken Frauwirth
-- 
Ken Frauwirth (MiSTie #33025)  kfrauwir at midway.uchicago.edu
Gwen Knapp Center for Lupus and Immunology Research
University of Chicago
http://www.ocf.berkeley.edu/~frauwirt



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