In article <34DA11D1.D0 at mail.tju.edu>, mark <mark.haynes at mail.tju.edu> writes:
>tfc2 at Lehigh.EDU wrote:
>>> I'm interested in your thoughts and opinions on the pros and cons of using
>> ascites vs cell culture for antibody production. We have used hollow fiber A
B
> > production in the past but there is a move in the company toward ascites.
> I
>> am not comfortable with this change and hope to understand the reasons for th
is
>> decision a little better, with your help.
>>>>> Thanks,
>> Theresa
>>Theresa, HI I don't know the exact yield comparisons between the two
>techniques, I presume that the ascites approach give higher yields. The cost
>is certainly related to animal costs. Are you questioning the technique's
>ability to produce ab or the 'means-to-an-end'?
> Well, both really. I would like to understand the reasons behind
my company's decision to switch to ascites production from culture
based on $$ savings,etc.
I'm finding it difficult to accept that the ascites benefit can
justify the move away from non-animal production of AB because I
question the use of animals for production purposes when there is
a viable non-animal alternative.
Cell culture served our company well many years
prior to this change. Can the cost savings be so staggering that
it's "worth" using this method?
