antibody production-ascites vs culture

tfc2 at Lehigh.EDU tfc2 at Lehigh.EDU
Thu Feb 5 14:10:16 EST 1998


In article <34DA11D1.D0 at mail.tju.edu>, mark <mark.haynes at mail.tju.edu> writes:
>tfc2 at Lehigh.EDU wrote:
>
>> I'm interested in your thoughts and opinions on the pros and cons of using
>> ascites vs cell culture for antibody production.  We have used hollow fiber A
B
> > production in the past but there is a move in the company toward ascites.
> I
>> am not comfortable with this change and hope to understand the reasons for th
is
>> decision a little better, with your help.
>
>>
>> Thanks,
>> Theresa
>
>Theresa, HI  I don't know the exact yield comparisons between the two
>techniques, I presume that the ascites approach give higher yields.  The cost
>is certainly related to animal costs.  Are you questioning the technique's
>ability to produce ab or the 'means-to-an-end'?
>
            Well, both really.  I would like to understand the reasons behind
            my company's decision to switch to ascites production from culture
            based on $$ savings,etc.
            I'm finding it difficult to accept that the ascites benefit can
            justify the move away from non-animal production of AB because I
            question the use of animals for production purposes when there is
            a viable non-animal alternative.
            Cell culture served our company well many years
            prior to this change.  Can the cost savings be so staggering that
            it's "worth" using this method?



More information about the Immuno mailing list