Dr Robertson,
I have not seen such a case as you describe, but have been interested in
the old assertion that congenital rubella may cause hypogammaglobulinaemia.
I was sceptical about this since it is not obviously a major cause of
immunodeficeincy. Also, some years ago I saw a handicapped 15 yr old boy
who was one of the original cases described as having low IgA low IgG and
raised IgM secondary to congenital rubella. On re-investigation he had
normal immunoglobulin levels and had not had excess infections in the
preceding years. Possibly congenital rubella may cause a heterogenous,
transient abnormality of immunoglobulin and antibody production. Best wishes.
Dr. Gareth Morgan
