Hi all,
I was just wondering if anyone knew of any good papers on theories
why when immunising with specific organisms or proteins the IgM
response dominates even after a full immunisation programme.
I've got one theory that some antigens (due to there
characteristics ie too large etc.) when introduced do not require the
help of T-Lymphocytes to stimulate B-Cells into antibody production .
Resulting in less isotype switching and reduced affinity maturation
of mabs produced.
Does anyone know any more theories?
Thanks in Advance
Chris Weir
Macquarie University
