anti-HLA mAbs

calman at nih.gov calman at nih.gov
Wed Feb 25 12:09:48 EST 1998


I have tried blocking of allergen stimulated CD4 T cells with just L243 and
only get partial blocking, presumably due to other restricting elements.
I get 90+% blocking of TB responses. I was hoping to kill 3 birds with one mAb
and find a single mAb that recognizes and blocks DR, DP and DQ rather than 3
different mAbs. Too good to be true, eh?

Calman

In article <34F3173A.3385 at mail.tju.edu>,
  mark <mark.haynes at mail.tju.edu> wrote:
>
> calman at nih.gov wrote:
> >
> > I am looking for an antibody or hybridoma to HLA-DR, DP, DQ that blocks
> > antigen presentation and/or MLR. Does anyone know of any sources for such a
> > mAb? Thanks.
>
> I don't know about the mlr inhibition but two moab that come to mind are
> the w632 (this designiation may be the clone name) and Lt34 or L234.
> Check atcc catalogue for these and other possibilities.
> markH
>


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