What does Class II HLA on human T cells do?

S.N. Imlach sni1 at le.ac.uk
Mon Jan 19 04:56:18 EST 1998

Expression of HLA Class II along with co-stimulatory molecules (e.g B-7)
has be shown to allow T cells to act as effective APCs. Activated T cells
can capture, process and present Ag to Class II-restricted T cells. This
capacity correlates with the synthesis of Class II. For further information
please refer to:

Barnaba V, Watts C, de Boer M , Lane P and Lanzavecchia A (1994)
Professional presentation of antigen by activated human T cells.
Eur. J. Immunol., Vol.24:p.71-75

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