CD8 T cells, CTL and IFNg

[Nagendra R Hegde]

I have an additional question to the one posted earlier (shown hereunder):

If one stimulates a T cell culture with an antigen and expects both Th and
CTLs to proliferate, is it possible for the CTLs to secrete more IFN-g
than Th cells?  Which type of cells, Th or CTL, secrete more IFN-g?
Again, references are welcome.

Thanks

Nag

> Hi
> 
> Just a simple but important question
> IFNg production and cells lysis are the two effector mecanisms of CD8 T
> cells.
> Does anybody knows whether CD8 T cells are able to produce IFNg and lyse
> target cells at the same time or sequentially. Alternatively, are there
> two distinct populations of CD8 T cells (with the same antigenic
> specificity of course) that produce IFNg and kill cells.
> 
> Any references wil be welcome.
> 
> Thanks
>