"Conditioning"--IL-1 et al.

F. Frank LeFever flefever at ix.netcom.com
Sat Jun 13 22:39:32 EST 1998


In <6li967$auu at dfw-ixnews8.ix.netcom.com> flefever at ix.netcom.com(F.
Frank LeFever) writes: 
>
>
>
>Still interested...
>
>Waiting...
>
>

DITTO JUNE 13, 1998; DO NOT ASSUME SOMEONE ELSE HAS ANSWERED!  SURELY
SOMEBODY MUST HAVE SOME DATA OR AT LEAST SOME LEADS!


>
>In <6ldaa6$ahc at dfw-ixnews9.ix.netcom.com> flefever at ix.netcom.com(F.
>Frank LeFever) writes: 
>>
>>There are many demonstrations of "conditioning" in the sense of acute
>>changes in reactions of one or the other system after some treatment
>or other (e.g. reaction to hypoxia an hour or so after mechanical
brain
>>trauma, or vice versa).
>>
>>I am not interested in these.
>>
>>I am looking for LONG-TERM "conditioning"--on the order of Pavlovian
>>conditioning or on the order of immnological "conditioning" (e.g.
>>specific antigen recognition, etc.).
>>
>>For example: IL-1 production can be increased by various
manipulations
>>(e.g. brain trauma, hypoxia, LPS exposure, etc.); does a REMOTE
>history of this  (e.g. at LEAST a few weeks prior) influence
subsequent
>IL-1 responses?  e.g. influence on threshold for stimulation, on
>latency of response, on rate of production, on co-production of (e.g.)
>IL-1a (endogenous competitive ligand), or--?
>>
>>Interested in brain but surely info from anyplace else (ovarian
>tissue, gut, heart, liver, whtever) could be useful.
>>
>>Not ONLY IL-1--what about TNF? NO? and (beond this realm) NGF et al.?
>>
>>re Pavlovian conditioning: 1987 paper on conditioning of mast cell
>>response (MacQueen) much cited, but don't know if actually replicated
>>or extended...
>>
>>Post to bionet.immunology OR email me direct OR (if longer
>>communication, reprint, etc.): FAX (914) 786-4978 (att: LeFever)
>>
>>MAIL:   F. Frank LeFever, Ph.D.
>>        Helen Hayes Hospital
>>        West Haverstraw, NY 10993, USA
>>
>




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